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norskBlar i forfatter "Svartberg, Johan"
Viser treff 1-20 av 20
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Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-09)Background Testosterone is the standard treatment for male hypogonadism, but there is uncertainty about its cardiovascular safety due to inconsistent findings. We aimed to provide the most extensive individual participant dataset (IPD) of testosterone trials available, to analyse subtypes of all cardiovascular events observed during treatment, and to investigate the effect of incorporating data ... -
Change in prevalence and severity of metabolic syndrome in the Sami and non-Sami population in rural Northern Norway using a repeated cross-sectional population-based study design: the SAMINOR Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-14)<p><i>Objective - </i>To examine the change in both the prevalence and severity of metabolic syndrome (MetS) in the Sami and non-Sami in Northern Norway due to a lack of knowledge regarding the development of MetS in this population. <p><i>Design - </i>Repeated cross-sectional study. <p><i>Setting - </i>The study is based on data from the SAMINOR 1 Survey (2003–2004, n=6550) and the SAMINOR 2 ... -
Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromso OGTT Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Hb 6.5% has recently been recommended as an alternative diagnostic criterion for diabetes. The aims of the study were to evaluate the effects of age, sex, and other factors on prevalence of diabetes and to compare risk profiles of subjects with diabetes when defined by Hb and glucose criteria. Subjects were recruited among participants in the longitudinal population-based Tromsø Study. Hb , fasting ... -
Epidemiology and health related quality of life in hypoparathyroidism in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-17)<b>Objective:</b> The epidemiology of hypoparathyroidism (HP) is largely unknown. We aimed to determine prevalence, etiologies, health related quality of life (HRQOL) and treatment pattern of HP.<br> <b>Methods:</b> Patients with HP and 22q11 deletion syndrome (DiGeorge syndrome) were identified in electronic hospital registries. All identified patients were invited to participate in a survey. ... -
Estimated 8-year cumulative incidence of diabetes mellitus among Sami and non-Sami inhabitants of Northern Norway - The SAMINOR Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-24)<i>Background</i>: The aim of the study was to estimate and compare the 8-year cumulative incidence of diabetes mellitus (DM) among Sami and non-Sami inhabitants of rural districts in Northern Norway.<p> <p><i>Methods</i>: Longitudinal study based on linkage of two cross-sectional surveys, the SAMINOR 1 Survey (2003–2004) and the SAMINOR 2 Clinical Survey (2012–2014). Ten municipalities in rural ... -
Estimated 8-year cumulative incidence of diabetes mellitus among Sami and non-Sami inhabitants of Northern Norway- The SAMINOR Study
(Journal article; Peer reviewed, 2019-06-24)<b>Background</b><br> The aim of the study was to estimate and compare the 8-year cumulative incidence of diabetes mellitus (DM) among Sami and non-Sami inhabitants of rural districts in Northern Norway. <br><b>Methods</b><br> Longitudinal study based on linkage of two cross-sectional surveys, the SAMINOR 1 Survey (2003–2004) and the SAMINOR 2 Clinical Survey (2012–2014). Ten municipalities in rural ... -
GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-11)Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P < 5 × 10−8). In addition to loci implicated in lymphocyte function and development shared with other ... -
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) ... -
Incidence of and risk factors for type-2 diabetes in a general population: The Tromso Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
A longitudinal follow-up of autoimmune polyendocrine syndrome type 1
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-02)<b>Context:</b> Autoimmune polyendocrine syndrome type 1 (APS1) is a childhood-onset monogenic disease defined by the presence of two of the three major components: hypoparathyroidism, primary adrenocortical insuffi- ciency, and chronic mucocutaneous candidiasis (CMC). Information on longitudinal follow-up of APS1 is sparse. <b>Objective:</b> To describe the phenotypes of APS1 and correlate the ... -
Obesity measures, metabolic health and their association with 15-year all-cause and cardiovascular mortality in the SAMINOR 1 Survey: a population-based cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-21)Background - The mortality of metabolic-obesity phenotypes has been thoroughly studied, but it is not known if or how the association between mortality and body mass index (BMI), waist circumference or a body shape index (ABSI) differ in strata of cardiometabolic health status.<p> <p>Methods - We linked data on 12,815 men and women aged 36–79 years from the SAMINOR 1 Survey with mortality data ... -
The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction and body height. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Objective: High serum thyrotropin (TSH) levels predict cardiovascular disease (CVD). Recently several single nucleotide polymorphisms (SNPs) associated with TSH levels have been identified, one of them being the rs4704397 SNP in the phosphodiesterase 8B (PDE8B) gene. If the relation between thyroid function and CVD is causal, one could also expect rs4704397 genotypes to predict CVD and possibly ... -
Plasma profile of microRNA after supplementation with high doses of vitamin D3 for 12 months
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-05-17)Background: Recently a large number of short non-coding-RNAs (microRNAs, (miRNA)) have been identified. These miRNAs act as post-transcriptional regulators where they generally have an inhibitory function. miRNAs are present in all human cells, and they are also detected in serum or plasma. The miRNAs have a broad range of actions, and their biogenesis must therefore be under tight control. One ... -
Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these ... -
The prevalence of diabetes mellitus among Sami and non-Sami inhabitants of Northern Norway - The SAMINOR 1 Survey (2003-2004) and the SAMINOR 2 Clinical Survey (2012-2014)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-14)<p><i>Introduction</i>: This study aimed to compare the prevalence of diabetes mellitus (DM) between Sami and non-Sami inhabitants of Northern Norway participating in the SAMINOR 1 Survey and the SAMINOR 2 Clinical Survey, and to track DM prevalence over time.</p> <p><i>Methods</i>: SAMINOR 1 (2003–2004) and SAMINOR 2 (2012–2014) are cross-sectional, population-based studies that each recruited ... -
Prevalence of pre-diabetes and type 2 diabetes mellitus among Sami and non-Sami men and women in Northern Norway – The SAMINOR 2 Clinical Survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-26)The aim of this study was to determine and compare the prevalence of pre-diabetes and type 2 diabetes mellitus (T2DM) among Sami and non-Sami men and women of rural districts in Northern Norway. The SAMINOR 2 Clinical Survey is a cross-sectional population-based study performed in 2012–2014 in 10 municipalities of Northern Norway. A total of 12,455 Sami and non-Sami inhabitants aged 40–79 years were ... -
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)Many incident cases of type 2 diabetes do not fulfill the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, and ... -
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010-12-28)Many incident cases of type 2 diabetes do not fulfil the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, ... -
Symptomatic benefits of testosterone treatment in patient subgroups: a systematic review, individual participant data meta-analysis, and aggregate data meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-04)Background Testosterone replacement therapy is known to improve sexual function in men younger than 40 years with pathological hypogonadism. However, the extent to which testosterone alleviates sexual dysfunction in older men and men with obesity is unclear, despite the fact that testosterone is being increasingly prescribed to these patient populations. We aimed to evaluate whether subgroups of men ... -
Thyroid function, as assessed by TSH, and future risk of venous thromboembolism: The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-21)Objective: The relationship between thyroid function and the risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the association between TSH levels and the risk of VTE in a general adult population. Design: Population-based cohort study. Methods: TSH was measured in 11 962 subjects aged 25–89 years who participated in Tromsø 4–6 starting in ...
